Abstract
The Omicron variant of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) spreads rapidly and harbors many mutations in the spike protein, but the origin of this virus variant remains unclear. We address the role of unusual virus evolution mechanisms such as hypermutation, out-of-frame reading, and recombination. Rather, regular Darwinian evolution, that is, the repeated selection of beneficial spike mutations, seems to have led to the appearance of the grossly altered spike protein of the Omicron variant.
Keywords: Omicron; SARS-CoV-2; evolution.
All Keywords
【저자키워드】 Evolution, SARS-CoV-2, omicron, 【초록키워드】 Evolution, coronavirus, Mutation, variant, severe acute respiratory syndrome Coronavirus, omicron, virus, Spike protein, Spread, Recombination, Omicron variant, spike mutations, mechanism, acute respiratory syndrome, Frame, acute respiratory syndrome coronavirus, acute respiratory syndrome coronavirus 2, appearance, hypermutation, repeated, the spike protein, 【제목키워드】 sudden,
【저자키워드】 Evolution, SARS-CoV-2, omicron, 【초록키워드】 Evolution, coronavirus, Mutation, variant, severe acute respiratory syndrome Coronavirus, omicron, virus, Spike protein, Spread, Recombination, Omicron variant, spike mutations, mechanism, acute respiratory syndrome, Frame, acute respiratory syndrome coronavirus, acute respiratory syndrome coronavirus 2, appearance, hypermutation, repeated, the spike protein, 【제목키워드】 sudden,
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중증급성호흡기증후군 코로나바이러스 2(SARS-CoV-2)의 오미크론 변종은 빠르게 확산되고 스파이크 단백질에 많은 돌연변이를 갖고 있지만 이 바이러스 변종의 기원은 아직 불분명합니다. 우리는 초돌연변이, 프레임 외 판독 및 재조합과 같은 비정상적인 바이러스 진화 메커니즘의 역할을 다룹니다. 오히려 규칙적인 다윈의 진화, 즉 유익한 스파이크 돌연변이의 반복적인 선택이 오미크론 변이체의 스파이크 단백질을 크게 변형시킨 것으로 보입니다.
{{ 키워드: }} 오미크론; 사스 코로나바이러스 2; 진화.