Abstract
Background: The clinical consequences of SARS-CoV-2 and DENGUE virus co-infection are not promising. However, their treatment options are currently unavailable. Current studies have shown that quercetin is both resistant to COVID-19 and DENGUE; this study aimed to evaluate the possible functional roles and underlying mechanisms of action of quercetin as a potential molecular candidate against COVID-19 and DENGUE co-infection.
Methods: We used a series of bioinformatics analyses to understand and characterize the biological functions, pharmacological targets and therapeutic mechanisms of quercetin in COVID-19 and DENGUE co-infection.
Results: We revealed the clinical characteristics of COVID-19 and DENGUE, including pathological mechanisms, key inflammatory pathways and possible methods of intervention, 60 overlapping targets related to the co-infection and the drug were identified, the protein-protein interaction (PPI) was constructed and TNFα, CCL-2 and CXCL8 could become potential drug targets. Furthermore, we disclosed the signaling pathways, biological functions and upstream pathway activity of quercetin in COVID-19 and DENGUE. The analysis indicated that quercetin could inhibit cytokines release, alleviate excessive immune responses and eliminate inflammation, through NF-κB, IL-17 and Toll-like receptor signaling pathway.
Conclusions: This study is the first to reveal quercetin as a pharmacological drug for COVID-19 and DENGUE co-infection. COVID-19 and DENGUE co-infection remain a potential threat to the world’s public health system. Therefore, we need innovative thinking to provide admissible evidence for quercetin as a potential molecule drug for the treatment of COVID-19 and DENGUE, but the findings have not been verified in actual patients, so further clinical drug trials are needed.
Keywords: COVID-19; DENGUE; co-infection; computational biology; quercetin.
【저자키워드】 COVID-19, Computational biology, quercetin, Dengue, Co-infection, 【초록키워드】 Treatment, public health, Biological functions, SARS-CoV-2, Inflammation, Cytokines, Clinical characteristics, Computational biology, bioinformatics, quercetin, Intervention, drug, virus, Toll-like receptor, biological function, Dengue, immune responses, therapeutic, Co-infection, pathway, target, targets, mechanisms, signaling pathways, patients, protein-protein interaction, mechanism, CXCL8, NF-κB, Evidence, Analysis, PPI, IL-17, clinical consequences, overlapping, treatment of COVID-19, TNFα, CCL-2, excessive immune response, upstream, pharmacological target, pharmacological, toll-like receptor signaling, current, drug trial, cytokines release, shown, evaluate, indicated, inhibit, functional, alleviate, clinical consequence, inflammatory pathway, potential molecular, 【제목키워드】 SARS-CoV-2, pathway, Critical, therapeutic strategy, Host, triggered,