Abstract
Purpose of review: This review investigated the potential role of microRNAs (miRNAs) in the synergy of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection, preeclampsia (PE), and human immunodeficiency virus (HIV) infection. Maternal health is a great concern when treating pregnant women fighting this triad of diseases, which is highly prevalent in South Africa. MicroRNAs are involved in fine-tuning of physiological processes. Disruptions to the balance of this minute protein can lead to various physiological changes that are sometimes pathological.
Recent findings: MicroRNAs have recently been implicated in PE and have been linked to the anti-angiogenic imbalance evident in PE. Recent in silico studies have identified potential host miRNAs with anti-viral properties against SARS-CoV-2 infection. Studies have demonstrated dysregulated expression of several miRNAs in HIV-1 infection along with the ability of HIV-1 to downregulate anti-viral host microRNAs. This review has highlighted the significant gap in literature on the potential of miRNAs in women with HIV-associated PE in synergy with the novel SARS-CoV-2 infection. In addition, this review has provided evidence of the critical role that the epigenetic regulatory mechanism of miRNA plays in viral infections and PE, thereby providing a foundation for further research investigating the potential of therapeutic miRNA development with fewer side-effects for pregnant women.
Keywords: Human immunodeficiency virus; Hypertension; MicroRNA; Preeclampsia; Pregnancy; SARS-CoV-2 infection.
【저자키워드】 SARS-COV-2 infection, microRNA, hypertension, preeclampsia, Pregnancy, Human immunodeficiency virus, 【초록키워드】 SARS-CoV-2, HIV, coronavirus, Diseases, SARS-COV-2 infection, Human, microRNA, miRNA, Infection, immunodeficiency, in silico, severe acute respiratory syndrome Coronavirus, hypertension, viral infections, Anti-viral, preeclampsia, Regulatory, pregnant women, Protein, Maternal, Pregnancy, South Africa, Health, miRNAs, therapeutic, HIV-1, Research, women, Human immunodeficiency virus, synergy, expression, MicroRNAs, Epigenetic, Critical, mechanism, Evidence, Disruption, physiological, evidence of, acute respiratory syndrome, Side-effect, acute respiratory syndrome coronavirus, acute respiratory syndrome coronavirus 2, immunodeficiency virus, foundation, host miRNA, silico studies, HIV-1 infection, Host, recent, prevalent, involved, addition, investigated, provided, in viral, demonstrated, dysregulated, implicated, downregulate, physiological change, 【제목키워드】 SARS-CoV-2, Involvement,