Full-length genomic sequences of hepatitis E virus (HEV) obtained from two consecutive cases of acute self-limiting hepatitis E in a city in northeast Japan were determined. Interestingly, two HEV isolates from each patient shared nucleotide identity of 99.97% in 7 225 nucleotides, and a phylogenetic analysis showed that they formed a cluster of Japanese isolates that is considered as a new HEV subtype 3k. The high similarity of HEV sequences of two isolates from these patients in this study suggested that a subtype 3k HEV strain had spread via a commonly distributed food in the city, possibly pig liver.
All Keywords
【저자키워드】 Phylogenetic analysis, full genome, hepatitis viruses, Genotype 3, subtype classification.,
【저자키워드】 Phylogenetic analysis, full genome, hepatitis viruses, Genotype 3, subtype classification.,