Abstract
On 30th January 2020, an outbreak of atypical pneumonia caused by a novel betacoronavirus, named severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), was declared a public health emergency of international concern by the World Health Organization. For this reason, a detailed evolutionary analysis of SARS-CoV-2 strains currently circulating in different geographic regions of the world was performed. A compositional analysis as well as a Bayesian coalescent analysis of complete genome sequences of SARS-CoV-2 strains recently isolated in Europe, North America, South America, and Asia was performed. The results of these studies revealed a diversification of SARS-CoV-2 strains in three different genetic clades. Co-circulation of different clades in different countries, as well as different genetic lineages within different clades were observed. The time of the most recent common ancestor was established to be around 1st November 2019. A mean rate of evolution of 6.57 × 10 -4 substitutions per site per year was found. A significant migration rate per genetic lineage per year from Europe to South America was also observed. The results of these studies revealed an increasing diversification of SARS-CoV-2 strains. High evolutionary rates and fast population growth characterizes the population dynamics of SARS-CoV-2 strains.
Keywords: SARS-CoV-2; coalescent; coronavirus; evolution.
【저자키워드】 Evolution, SARS-CoV-2, coronavirus, coalescent, 【초록키워드】 Evolution, coronavirus, Europe, Bayesian, Pneumonia, Genetic, severe acute respiratory syndrome Coronavirus, Betacoronavirus, Asia, Region, Migration, outbreak, International, Population dynamics, Lineage, substitutions, clade, clades, public health emergency, respiratory, South America, Strains, Analysis, migration rate, Evolutionary rate, genome sequence, Atypical pneumonia, Atypical, Health Organization, population growth, World Health Organization, acute respiratory syndrome, acute respiratory syndrome coronavirus, acute respiratory syndrome coronavirus 2, growth, novel Betacoronavirus, North America, Substitution, circulating, SARS-CoV-2 strains, SARS-CoV-2 strain, Complete, caused, was performed, 【제목키워드】 coronavirus, coronavirus 2, respiratory, strain, evidence of,