Abstract
The COVID-19 pandemic induced by the SARS-CoV-2 virus and its variants has ravaged most countries around the world including Bangladesh. We have analyzed publicly available genomic data to understand the current COVID-19 outbreak scenario as well as the evolutionary origin and transmission routes of SARS-CoV-2 isolates in Bangladesh. All the early isolates as well as recent B.1.1.7 and B.1.351 variants had already spread across the major divisional cities of Bangladesh. A sex biasness towards male COVID-19 patient samples sequencing has been observed over female patient samples in all age-group, that could be the trend in infection rate. Phylogenetic analysis indicated a total of 13 estimated countries, including Italy, India, United Kingdom, Saudi Arabia, United Arab Emirates, Germany, Australia, New Zealand, South Africa, Democratic Republic of the Congo, United States, Russia, and Denmark, could be the possible origin introduced SARS-CoV-2 isolates in Bangladesh because of regional and intercontinental travel. Recent, B.1.1.7 variant could be imported from a total of 7 estimated countries including UK, India, Nigeria, Spain, Ireland, Australia, and Indonesia, while South Africa and the United States are the most likely sources of B.1.351 variant in Bangladesh. Based on these findings, public health strategies could be designed and implemented to reduce the local transmission of the virus.
Keywords: B.1.1.7; B.1.351; Bangladesh; COVID-19; Epidemiology; SARS-CoV-2.
【저자키워드】 COVID-19, SARS-CoV-2, Epidemiology, B.1.351, Bangladesh, B.1.1.7, 【초록키워드】 public health, SARS-CoV-2, B.1.351, COVID-19 pandemic, United Arab Emirates, Sequencing, India, Russia, variant, Sex, SARS-CoV-2 virus, Local, Transmission, Nigeria, Italy, virus, Saudi Arabia, Spread, Phylogenetic analysis, South Africa, B.1.1.7 variant, COVID-19 outbreak, Germany, B.1.1.7, male, female, Patient, Indonesia, Travel, Spain, Ireland, transmission route, infection rate, United States, United Kingdom, Denmark, Transmission routes, Analysis, B.1.351 variants, COVID-19 patient, Democratic Republic, B.1.351 variant, genomic data, SARS-CoV-2 isolates, isolate, recent, country, analyzed, indicated, the United State, introduced, reduce, New, SARS-CoV-2 isolate, the SARS-CoV-2 virus, 【제목키워드】 variants of concern, SARS-CoV-2 genome, transmission route,