Abstract
The need for new coronavirus disease 2019 (COVID-19) therapeutic strategies continues, especially as severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variants emerge. Zhang and colleagues elegantly engineered a mutant angiotensin-converting enzyme 2 (ACE2) that competitively binds SARS-CoV-2 spike protein, reduces viral uptake by human lung cells, and ameliorates SARS-CoV-2-induced lung injury in mice expressing human ACE2.
Keywords: ARDS; COVID-19 therapy; viral pneumonia.
All Keywords
【저자키워드】 ARDS, Viral pneumonia, COVID-19 therapy, 【초록키워드】 COVID-19, coronavirus disease, SARS-CoV-2, Coronavirus disease 2019, ACE2, ARDS, coronavirus, variant, Lung injury, severe acute respiratory syndrome Coronavirus, angiotensin-converting enzyme 2, Spike protein, human ACE2, Viral pneumonia, mice, SARS-CoV-2 spike protein, Therapeutic strategies, COVID-19 therapy, mutant, disease, therapeutic strategy, New coronavirus, angiotensin, acute respiratory syndrome, acute respiratory syndrome coronavirus, acute respiratory syndrome coronavirus 2, human lung cells, bind, reduce, expressing, 【제목키워드】 COVID-19, ACE2, mutant, reduce,
【저자키워드】 ARDS, Viral pneumonia, COVID-19 therapy, 【초록키워드】 COVID-19, coronavirus disease, SARS-CoV-2, Coronavirus disease 2019, ACE2, ARDS, coronavirus, variant, Lung injury, severe acute respiratory syndrome Coronavirus, angiotensin-converting enzyme 2, Spike protein, human ACE2, Viral pneumonia, mice, SARS-CoV-2 spike protein, Therapeutic strategies, COVID-19 therapy, mutant, disease, therapeutic strategy, New coronavirus, angiotensin, acute respiratory syndrome, acute respiratory syndrome coronavirus, acute respiratory syndrome coronavirus 2, human lung cells, bind, reduce, expressing, 【제목키워드】 COVID-19, ACE2, mutant, reduce,
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특히 중증급성호흡기증후군 코로나바이러스 2(SARS-CoV-2) 변종이 출현함에 따라 새로운 코로나바이러스 질병 2019(COVID-19) 치료 전략의 필요성이 계속되고 있습니다. Zhang과 동료들은 SARS-CoV-2 스파이크 단백질에 경쟁적으로 결합하고 인간 폐 세포에 의한 바이러스 흡수를 감소시키며 인간 ACE2를 발현하는 마우스에서 SARS-CoV-2 유도 폐 손상을 개선하는 돌연변이 안지오텐신 전환 효소 2(ACE2)를 우아하게 조작했습니다. .
{{ 키워드: }} ARDS; 코로나19 치료; 바이러스성 폐렴.