Abstract
Three COVID-19 waves in Japan have been characterized by the presence of distinct PANGO lineages (B.1.1. 162, B.1.1.284, and B.1.1.214). Recently, in addition to the B.1.1.7 lineage, which shows 25% abundance, an R.1 lineage carrying the E484K mutation in the spike protein was found to show up to 40% predominance. E484K could be a pivotal amino acid substitution with the potential to mediate immune escape; thus, more attention should be paid to such potential variants of concern to avoid the emergence of mutants of concern. Such comprehensive real-time genome surveillance has become essential for the containment of COVID-19 clusters.
Keywords: COVID-19; E484K; Immune escape; Mutation of concern; R.1; SARS-CoV-2; Spatiotemporal distribution; Spike protein.
【저자키워드】 COVID-19, SARS-CoV-2, Spike protein, Immune escape, E484K, mutation of concern, R.1, Spatiotemporal distribution, 【초록키워드】 Mutation, spike, Genome, variants of concern, immune, Spike protein, B.1.1.7 lineage, Protein, Surveillance, Immune escape, B.1.1.7, Lineage, Clusters, Japan, E484K, mutants, mutant, E484K mutation, Containment, Amino acid, B.1.1, amino acid substitution, addition, characterized, the spike protein, 【제목키워드】 coronavirus, Lineage, acute respiratory syndrome, increase in,