Abstract
The severity of COVID-19 has been observed throughout the world as severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) globally claimed more than 2 million lives and left a devastating impact worldwide. Recently several virulent mutant strains of this virus, such as the B.1.1.7, B.1.351, and P1 lineages, have emerged with initial predominance in UK, South Africa, and Brazil. Another extremely pathogenic B.1.617 lineage and its sub-lineages, first detected in India, are now affecting some countries at notably stronger spread-rates. The present paper computationally examines the time-based structures of B.1.1.7, B.1.351, and P1 lineages with selected spike protein mutations. The mutations in the more recently found B.1.617 lineage and its sub-lineages are explored, and the implications for multiple point mutations of the spike protein’s receptor-binding domain (RBD) are described. The selected S1 mutations within the highly contagious B.1.617.2 sub-lineage, also known as the delta variant, are examined as well.
Keywords: Mutation; SARS-CoV-2 lineages; Spike protein; Structural biochemistry; Variants, Virus structure.
【저자키워드】 Mutation, Spike protein, SARS-CoV-2 lineages, Structural biochemistry, Variants, Virus structure., 【초록키워드】 Brazil, Structure, SARS-CoV-2, coronavirus, Mutation, spike, B.1.351, India, mutations, variant, B.1.617.2, severe acute respiratory syndrome Coronavirus, delta variant, virus, variants, Spike protein, South Africa, B.1.1.7, RBD, severity of COVID-19, B.1.617, Lineage, lineages, Point mutation, mutant strain, acute respiratory syndrome, acute respiratory syndrome coronavirus, acute respiratory syndrome coronavirus 2, domain, pathogenic, contagious, virulent, implication, country, initial, Virulent mutant, selected, described, examined, the spike protein, affecting, claimed, 【제목키워드】 Analysis, Comparative, SARS-CoV-2 lineage, selected,