Abstract
Toll-like receptor 3 (TLR3) and TLR7 genes are involved in the host immune response against viral infections including SARS-COV-2. This study aimed to investigate the association between the TLR3(rs3775290) and TLR7(rs179008) polymorphisms with the prognosis and susceptibility to COVID-19 pneumonia accompanying SARS-COV-2 infection. This case-control study included 236 individuals: 136 COVID-19 pneumonia patients and 100 age and sex-matched controls. Two polymorphisms (TLR3 rs3775290 and TLR7 rs179008) were genotyped by allelic discrimination through TaqMan real-time PCR. This study also investigated predictors of mortality in COVID-19 pneumonia through logistic regression. The mutant ‘T/T’ genotypes and the ‘T’ alleles of TLR3(rs3775290) and TLR7(rs179008) polymorphisms were significantly associated with increased risk of COVID-19 pneumonia. This study did not report association between the mutant ‘T/T’ genotypes of TLR3(rs3775290) and TLR7(rs179008) and the disease outcome. In multivariate analysis, the independent predictors of mortality in COVID-19 pneumonia were male sex, SPO 2 ≤ 82%, INR > 1, LDH ≥ 1000 U/l, and lymphocyte count<900/mm3 (P < 0.05).
Keywords: COVID-19 pneumonia; Gene polymophism; Real time PCR; Risk factors; Toll-like receptors.
【저자키워드】 COVID-19 pneumonia, Risk factors, real time PCR, Gene polymophism, Toll-like receptors., 【초록키워드】 COVID-19, viral infection, COVID-19 pneumonia, Risk factors, Mortality, Prognosis, Pneumonia, SARS-COV-2 infection, susceptibility, Infection, TLR7, polymorphism, LDH, outcome, viral infections, Polymorphisms, lymphocyte, Host immune response, Real-time PCR, Genotype, Logistic regression, age, Toll-like receptors, mutant, predictor, real time PCR, case-control study, association, TLR3, Multivariate analysis, Analysis, Male sex, independent predictors, increased risk, allele, TaqMan, TLR7 gene, controls, Toll-like receptor 3, significantly, involved, investigated, the disease, allelic, genotyped, COVID-19 pneumonia patient, independent predictor, INR, SPO, 【제목키워드】 COVID-19, polymorphism, outcome, Toll-like receptor, case-control study,