Objective The dramatic spread of SARS-CoV-2 infections calls for reliable, inexpensive tools to quickly identify patients with a poor prognosis. In this study, acute respiratory distress syndrome (ARDS) was assessed within 72 h after admission of each of 153 consecutive, SARS-CoV-2 infected, adult patients to either of two hospitals in Tenerife, Spain, using suitable routine laboratory tests for lymphocyte counts, as well as ferritin, lactate dehydrogenase (LDH), and C-reactive protein levels. Results were correlated with the patients’ respiratory function, defined through their pulse oximetric saturation/fraction of inspired oxygen (SpO2/FiO2) ratio. Results Within 72 h from admission, criteria matched ARDS (SpO2/FiO2 < 235) in 13.1% of cases. We found a significant, negative correlation between SpO2/FiO2 ratios and d -dimer, ferritin, and LDH levels (− 0.31, − 0.32, and − 0.41; p = 0.004, 0.004, and < 0.0001, respectively). In patients with ARDS, the mean LDH was 373 U/L (CI 95% : 300.6–445.3), but only 298 U/L (CI 95% : 274.7–323.1) when they did not develop the syndrome (p = 0.015). None of the additionally evaluated biomarkers correlated with the SpO2/FiO2 ratios. Serum LDH levels in patients hospitalised for COVID-19 correlate with ARDS, as defined by their SpO2/FiO2 ratio, and might help to predict said complication.
【저자키워드】 COVID-19, Biomarkers, LDH, Acute respiratory failure, 【초록키워드】 SARS-CoV-2, ARDS, Biomarker, acute respiratory distress syndrome, Respiratory function, SARS-COV-2 infection, hospital, C-reactive protein, ferritin, oxygen, Laboratory tests, lactate dehydrogenase, Spread, lymphocyte, Patient, Spain, Complication, Admission, SARS-CoV-2 infections, predict, acute respiratory distress, Lactate, criteria, Laboratory test, respiratory distress, FiO2, SpO2, Adult patients, syndrome, poor prognosis, help, negative correlation, lymphocyte counts, d -dimer, SpO2/FiO2, pulse, hospitalised, objective, Result, defined, identify, develop, evaluated, correlated, the mean, patients with ARDS, 【제목키워드】 Infection, acute respiratory distress, respiratory distress, island, hospitalised, severe SARS-CoV-2,