Abstract
SARS-CoV-2 virus is the cause of COVID-19 pandemic and belongs to RNA viruses, showing great tendency to mutate. Several dozens of mutations have been observed on the SARS-CoV-2 virus, during the last two years. Some of the mutated strains show a greater infectivity and are capable of suppressing the earlier strains, through interference. In this work, kinetic and thermodynamic properties were calculated for strains characterized by various numbers and locations of mutations. It was shown that mutations lead to changes in chemical composition, thermodynamic properties and infectivity. Through competition, the phenomenon of interference of various SARS-CoV-2 strains was explained, which results in suppression of the wild type by mutant strains. Standard Gibbs energy of binding and binding constant for the Omicron (B.1.1.529) strain were found to be Δ B G⁰ = -45.96 kJ/mol and K B = 1.13 ∙ 10 +8 M -1 , respectively.
Keywords: Alpha strain; Beta strain; Delta strain; Gamma strain; Hu-1 strain; Omicron strain.
【저자키워드】 Delta strain, Alpha strain, Beta strain, Gamma strain, Hu-1 strain, Omicron strain., 【초록키워드】 SARS-CoV-2, Mutation, COVID-19 pandemic, mutations, Delta, SARS-CoV-2 virus, omicron, virus, RNA viruses, Gamma, Beta, B.1.1.529, Strains, wild type, binding, Mutant strains, strain, kinetic, Standard, Interference, suppression, phenomenon, SARS-CoV-2 strain, competition, greater, shown, characterized, calculated, changes in, explained, mutated, mutate, thermodynamic, binding constant, the SARS-CoV-2 virus, 【제목키워드】 SARS-CoV-2 variant, binding,