Abstract
During the COVID-19 pandemic, genetic variants of SARS-CoV-2 have been emerging and spreading around the world. Several SARS-CoV-2 endemic variants were found in United Kingdom, South Africa, Japan, and India between 2020 and April 2021. Studies have shown that many SARS-CoV-2 variants are more infectious than early wild strain and produce immune escape. These SARS-CoV-2 variants have brought new challenges to the prevention and control of COVID-19. This review summarizes and analyzes the biological characteristics of different amino acid mutations and the epidemic characteristics and immune escape of different SARS-CoV-2 variants. We hope to provide scientific reference for the monitoring, prevention, and control measures of new SARS-CoV-2 variants and the development strategy of the second-generation vaccine.
Keywords: COVID-19; SARS-CoV-2 variants; immune escape; mutations.
【저자키워드】 COVID-19, mutations, Immune escape, SARS-CoV-2 variants, 【초록키워드】 SARS-CoV-2, Vaccine, Mutation, COVID-19 pandemic, India, mutations, variant, SARS-CoV-2 variant, immune, South Africa, Characteristics, Immune escape, SARS-CoV-2 variants, Japan, genetic variants, Genetic variant, United Kingdom, Prevention and control, Amino acid, Endemic, wild strain, measure, the epidemic, new SARS-CoV-2, shown, 【제목키워드】 SARS-CoV-2 variant, Epidemic,