Abstract
COVID orchitis (testicular pain) is reported in 10-15% of men with long COVID. We identified 2 siblings with COVID orchitis and hypothesized that genetic mutations are associated with susceptibility. Blood samples from 5 COVID-19 (+) men, three of whom had orchitis were evaluated by whole-exome-sequencing. A rare deletion on chromosome 7 was found in NACAD among the 3 men with orchitis. Interestingly, circulating ACE2 levels was decreased in men with COVID orchitis. This pilot study generated the hypothesis that men who develop COVID orchitis could have underlying genetic variants and altered levels in circulating ACE2 that may increase their risk.
All Keywords
【초록키워드】 COVID-19, ACE2, susceptibility, risk, COVID, Genetic variant, Hypothesis, genetic mutation, genetic mutations, chromosome, Blood samples, pilot study, blood sample, circulating, chromosome 7, orchitis, men, testicular pain, NACAD, develop, reported, evaluated, 【제목키워드】 COVID, cause, Brother,
【초록키워드】 COVID-19, ACE2, susceptibility, risk, COVID, Genetic variant, Hypothesis, genetic mutation, genetic mutations, chromosome, Blood samples, pilot study, blood sample, circulating, chromosome 7, orchitis, men, testicular pain, NACAD, develop, reported, evaluated, 【제목키워드】 COVID, cause, Brother,
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COVID 고환염(고환 통증)은 장기간 COVID에 걸린 남성의 10-15%에서 보고됩니다. 우리는 COVID 고환염에 걸린 형제 2명을 확인하고 유전적 돌연변이가 감수성과 관련이 있다고 가정했습니다. 5명의 COVID-19(+) 남성의 혈액 샘플(그 중 3명은 고환염이 있음)을 전체 엑솜 시퀀싱으로 평가했습니다. 고환염이 있는 3명의 남성 중 NACAD에서 염색체 7의 드문 결실이 발견되었습니다. 흥미롭게도, 순환 ACE2 수치는 COVID 고환염이 있는 남성에서 감소했습니다. 이 파일럿 연구는 COVID 고환염이 발병하는 남성이 기저 유전적 변이를 갖고 순환하는 ACE2의 수준을 변경하여 위험을 증가시킬 수 있다는 가설을 생성했습니다.