Abstract
Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2), the causative agent of the current COVID-19 pandemic, has evolved to have a wide range of hosts, including non-human primates, wild and domestic animals. The ACE2 protein has a high level of conservation and is the common receptor invertebrate species for a viral infection to occur; this receptor could give rise to anthroponotic events. This article describes the first event of symptomatic transmission in Latin America from a human to a dog by the B.1.625 lineage of SARS-CoV-2. We found 21 shared mutations in the complete genomes of viral sequences from owners and dogs. Further phylogenetic and molecular analysis showed that 100% co-localization of the clade helps to understand human-animal transmission. Prediction of the Spike protein structure of the sequenced virus and docking analyzes showed that the E484K mutation in the receptor-binding domain (RBD) could contribute to the viral affinity of dACE2. Therefore, close contact between SARS-CoV-2-infected humans and pets should be avoided to prevent the emergence of novel mutations of public health importance from anthroponotic events.
【초록키워드】 public health, SARS-CoV-2, viral infection, Mutation, COVID-19 pandemic, Human, Genome, prediction, Transmission, docking, severe acute respiratory syndrome Coronavirus, virus, coronavirus 2, Spike protein, Severe acute respiratory syndrome, Protein, Receptor-binding domain, RBD, non-human primates, Latin America, symptomatic, Lineage, clade, protein structure, E484K, receptor, E484K mutation, respiratory, conservation, Localization, molecular analysis, ACE2 protein, close contact, Phylogenetic, causative agent, acute respiratory syndrome coronavirus, acute respiratory syndrome coronavirus 2, help, hosts, viral sequences, Complete, Prevent, sequenced, viral sequence, events, contribute, the receptor-binding domain, the Spike, 【제목키워드】 transmission of SARS-CoV-2,