Abstract
The devastating impact of the ongoing coronavirus disease 2019 (COVID-19) on public health, caused by the Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) has made targeting the COVID-19 pandemic a top priority in medical research and pharmaceutical development. Surveillance of SARS-CoV-2 mutations is essential for the comprehension of SARS-CoV-2 variant diversity and their impact on virulence and pathogenicity. The SARS-CoV-2 open reading frame 10 (ORF10) protein interacts with multiple human proteins CUL2, ELOB, ELOC, MAP7D1, PPT1, RBX1, THTPA, TIMM8B, and ZYG11B expressed in lung tissue. Mutations and co-occurring mutations in the emerging SARS-CoV-2 ORF10 variants are expected to impact the severity of the virus and its associated consequences. In this article, we highlight 128 single mutations and 35 co-occurring mutations in the unique SARS-CoV-2 ORF10 variants. The possible predicted effects of these mutations and co-occurring mutations on the secondary structure of ORF10 variants and host protein interactomes are presented. The findings highlight the possible effects of mutations and co-occurring mutations on the emerging 140 ORF10 unique variants from secondary structure and intrinsic protein disorder perspectives.
Keywords: And ubiquitin ligase complex; Co-occurring mutations; Intrinsic protein disorder; ORF10; SARS-CoV-2.
【저자키워드】 SARS-CoV-2., ORF10, And ubiquitin ligase complex, Co-occurring mutations, Intrinsic protein disorder, 【초록키워드】 COVID-19, coronavirus disease, severe acute respiratory syndrome coronavirus 2, public health, SARS-CoV-2, Coronavirus disease 2019, Mutation, COVID-19 pandemic, severity, variant, SARS-CoV-2 variant, severe acute respiratory syndrome Coronavirus, virus, coronavirus 2, variants, Protein, Consequences, Research, SARS-CoV-2 mutations, SARS-CoV-2 mutation, respiratory, pathogenicity, virulence, ORF10, Open reading frame, secondary structure, Frame, acute respiratory syndrome coronavirus, human proteins, host protein, lung tissue, single mutation, disorder, comprehension, ubiquitin ligase, Effect, ZYG11B, CUL2, highlight, RBX1, ELOB, ELOC, MAP7D1, PPT1, THTPA, TIMM8B, intrinsic, predicted, caused, unique, expressed, interact, expected, human protein, 【제목키워드】 SARS-CoV-2, variant, Protein, emergence, unique,