Abstract
SARS-CoV-2 variants emerged in late 2020, and at least three variants of concern (B.1.1.7, B.1.351, and P1) have been reported by WHO. These variants have several substitutions in the spike protein that affect receptor binding; they exhibit increased transmissibility and may be associated with reduced vaccine effectiveness. In the present work, we report the identification of a potential variant of interest, harboring the mutations T478K, P681H, and T732A in the spike protein, within the newly named lineage B.1.1.519, that rapidly outcompeted the preexisting variants in Mexico and has been the dominant virus in the country during the first trimester of 2021.
All Keywords
【초록키워드】 SARS-CoV-2, Vaccine, Mutation, B.1.351, variant, variants of concern, virus, Spike protein, Transmissibility, SARS-CoV-2 variants, B.1.1.7, Lineage, Effectiveness, WHO, receptor, P681H, first trimester, Receptor binding, T478K, Substitution, dominant, Affect, country, reported, reduced, the spike protein, 【제목키워드】 SARS-CoV-2, variant, Spread, emergence,
【초록키워드】 SARS-CoV-2, Vaccine, Mutation, B.1.351, variant, variants of concern, virus, Spike protein, Transmissibility, SARS-CoV-2 variants, B.1.1.7, Lineage, Effectiveness, WHO, receptor, P681H, first trimester, Receptor binding, T478K, Substitution, dominant, Affect, country, reported, reduced, the spike protein, 【제목키워드】 SARS-CoV-2, variant, Spread, emergence,
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SARS-CoV-2 변종은 2020년 말에 나타났으며, WHO는 최소 세 가지 우려 변종(B.1.1.7, B.1.351 및 P1)을 보고했습니다. 이러한 변이체는 수용체 결합에 영향을 미치는 스파이크 단백질에 여러 치환이 있습니다. 그들은 증가된 전염성을 나타내며 감소된 백신 효과와 관련될 수 있습니다. 현재 작업에서 우리는 새로 명명된 계통 B.1.1.519 내에서 스파이크 단백질에 돌연변이 T478K, P681H 및 T732A를 보유하고 있는 잠재적 관심 변이체의 식별을 보고합니다. 2021년 첫 삼분기 동안 이 나라에서 지배적인 바이러스였습니다.