Abstract
Infection by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the virus that causes coronavirus disease (COVID-19), has spread widely around the globe. Significant inter-individual differences have been observed during the course of the infection, which suggests that genetic susceptibility may be a contributing factor. CC chemokine receptor 5 (CCR5), which acts as a co-receptor for the entry of HIV-1 into cells, is promising candidate whose can have an influence on SARS-CoV-2 infection. A genetic mutation known as CCR5Delta32, consisting of a 32-nucleotide deletion, encodes a truncated protein that protects homozygous carriers of the deletion from HIV-1 infection. Similarly, inhibition of CCR5 seems to be protective against COVID-19. In our study, we successfully genotyped 416 first-wave SARS-CoV-2-positive infection survivors (164 asymptomatic and 252 symptomatic) for CCR5?32, comparing them with a population based sample of 2,404 subjects. We found the highest number (P=0.03) of CCR5Delta32 carriers in SARS-CoV-2-positive/COVID-19-asympto-matic subjects (23.8 %) and the lowest number in SARS-CoV-2-positive/COVID-19-symptomatic patients (16.7 %), with frequency in the control population in the middle (21.0 %). We conclude that the CCR5?32 I/D polymorphism may have the potential to predict the severity of SARS-CoV-2 infection.
【초록키워드】 COVID-19, coronavirus disease, SARS-CoV-2, coronavirus, Mutation, SARS-COV-2 infection, severity, Genetic, Infection, severe acute respiratory syndrome Coronavirus, virus, Spread, Protein, Asymptomatic, cells, symptomatic, HIV-1, Patient, Deletion, genetic susceptibility, receptor, Chemokine receptor, CCR5, predict, Protective, Frequency, I/D polymorphism, genetic mutation, acute respiratory syndrome, acute respiratory syndrome coronavirus, acute respiratory syndrome coronavirus 2, subject, carriers, candidate, homozygous, carrier, HIV-1 infection, ENCODE, survivor, middle, first-wave, lowest, PROTECT, Course, highest, globe, subjects, cause, genotyped, Significant, inter-individual, 【제목키워드】 COVID-19, subject, protective factor, first-wave,