Abstract
In January 2020, we identified two severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)-infected patients in a familial cluster with one person coming from Wuhan, China. The complete genome sequences of two SARS-CoV-2 strains isolated from these patients were identical and 99.98% similar to strains isolated in Wuhan. This is genetically suggestive of human-to-human transmission of SARS-CoV-2 and indicates Wuhan as the most plausible origin of the early outbreak in Vietnam. The younger patient had a mild upper respiratory illness and a brief viral shedding, whereas the elderly with multi-morbidity had pneumonia, prolonged viral shedding, and residual lung damage. The evidence of nonsynonymous substitutions in the ORF1ab region of the viral sequence warrants further studies.
Keywords: COVID-19; SARS-CoV-2; Vero; complete genome sequencing; coronavirus; respiratory infections.
【저자키워드】 COVID-19, respiratory infections, SARS-CoV-2, coronavirus, Complete genome sequencing, Vero, 【초록키워드】 respiratory infections, coronavirus, Pneumonia, Genome, viral shedding, Respiratory illness, Viral, outbreak, Wuhan, morbidity, Patient, Cluster, Mild, respiratory, prolonged viral shedding, Strains, Evidence, genome sequence, Vero, strain, ORF1ab, lung damage, evidence of, acute respiratory syndrome, acute respiratory syndrome coronavirus, acute respiratory syndrome coronavirus 2, sequence, human-to-human transmission, Complete, Wuhan, China, nonsynonymous substitutions, two SARS-CoV-2 strains, upper respiratory, indicate, nonsynonymous substitution, two SARS-CoV-2 strain, 【제목키워드】 coronavirus, Features, clinical, Patient, Isolation, genome sequence, acute respiratory syndrome, Complete,