Abstract
The factors that may contribute to a COVID-19 patient remaining in the asymptomatic stage, or to the infection evolving into the more serious stages are examined. In particular, we refer to the TMPRSS2 expression profile, balance of androgen and estrogen, blood group-A and/or B, nonsynonymous mutations in ORF3, and proteins NS7b and NS8 in SARS-CoV-2. Also, we review other factors related to the susceptibility and pathogenicity of SARS-CoV-2.
Keywords: 25-Hydroxyvitamin D (25(OH)D); ACE2; Androgen; Asymptomatic; Blood group; COVID-19 infection; Factors; Histocompatibility complex (MHC) class I; Mutation.
All Keywords
【저자키워드】 ACE2, Mutation, Asymptomatic, COVID-19 infection, Factors, Blood Group, androgen, 25-Hydroxyvitamin D (25(OH)D), Histocompatibility complex (MHC) class I, TMPRSS2, 【초록키워드】 COVID-19, SARS-CoV-2, Mutation, susceptibility, 25-hydroxyvitamin D, Infection, Estrogen, Protein, Asymptomatic, COVID-19 infection, pathogenicity, MHC, Blood, Blood Group, histocompatibility, androgen, Nonsynonymous mutations, COVID-19 patient, balance, ORF3, Factor, complex, Stage, TMPRSS2 expression, nonsynonymous mutation, examined, contribute, 【제목키워드】 Severe COVID-19 Infection, Factor,
【저자키워드】 ACE2, Mutation, Asymptomatic, COVID-19 infection, Factors, Blood Group, androgen, 25-Hydroxyvitamin D (25(OH)D), Histocompatibility complex (MHC) class I, TMPRSS2, 【초록키워드】 COVID-19, SARS-CoV-2, Mutation, susceptibility, 25-hydroxyvitamin D, Infection, Estrogen, Protein, Asymptomatic, COVID-19 infection, pathogenicity, MHC, Blood, Blood Group, histocompatibility, androgen, Nonsynonymous mutations, COVID-19 patient, balance, ORF3, Factor, complex, Stage, TMPRSS2 expression, nonsynonymous mutation, examined, contribute, 【제목키워드】 Severe COVID-19 Infection, Factor,
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COVID-19 환자가 무증상 단계에 머물거나 감염이 더 심각한 단계로 발전하는 데 기여할 수 있는 요인을 조사합니다. 특히, 우리는 TMPRSS2 발현 프로파일, 안드로겐과 에스트로겐의 균형, 혈액형 A 및/또는 B, ORF3의 비동의 돌연변이, SARS-CoV-2의 NS7b 및 NS8 단백질을 참조합니다. 또한 SARS-CoV-2의 감수성 및 병원성과 관련된 다른 요소를 검토합니다.
{{ 키워드: }} 25-하이드록시비타민 D(25(OH)D); ACE2; 안드로겐; 무증상; 혈액형; 코로나19 감염; 요인; 조직적합성 복합체(MHC) 클래스 I; 돌연변이.