Abstract
Alpha1-antitrypsin deficiency arises due to mutations in alpha1-antitrypsin (AAT) gene and represents the most prominent genetic predisposition to chronic obstructive pulmonary disease and emphysema. Since AAT plays important immunomodulatory and tissue-protective roles and since it was suggested to protect from severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection, we assessed this association in United Kingdom Biobank, a community-based cohort with >500,000 participants. The most common, mild AATD genotypes were associated neither with increased SARS-CoV-2 infection rates nor with increased SARS-CoV-2 fatalities, while the numbers of severe AATD cases were too low to allow definitive conclusions.
Keywords: AAT; AATD; SARS-CoV2.
【저자키워드】 SARS-CoV2, AAT, AATD, 【초록키워드】 SARS-CoV-2, coronavirus, SARS-CoV2, Mutation, SARS-COV-2 infection, Infection, severe acute respiratory syndrome Coronavirus, Biobank, immunomodulatory, Genotype, Mild, United Kingdom, pulmonary disease, association, Alpha1-antitrypsin, chronic obstructive pulmonary disease, Genetic predisposition, obstructive pulmonary disease, Community-based cohort, deficiency, acute respiratory syndrome, Participants, acute respiratory syndrome coronavirus, acute respiratory syndrome coronavirus 2, emphysema, antitrypsin, PROTECT, suggested, arise, chronic obstructive, 【제목키워드】 deficiency,