Coronavirus disease 2019 (COVID-19), a severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) causes infectious disease, and manifests in a wide range of symptoms from asymptomatic to severe illness and even death. Severity of infection is related to many risk factors, including aging and an array of underlying conditions, such as diabetes, hypertension, chronic obstructive pulmonary disease (COPD), and cancer. It remains poorly understood how these conditions influence the severity of COVID-19. Expansion of the CD28 null senescent T-cell populations, a common phenomenon in aging and several chronic inflammatory conditions, is associated with higher morbidity and mortality rates in COVID-19. Here, we summarize the potential mechanisms whereby CD28 null cells drive adverse outcomes in disease and predispose patients to devastating COVID-19, and discuss possible treatments for individuals with high counts of CD28 null senescent T-cells.
【저자키워드】 COVID-19, Inflammation, CD28null T-cells, senescence, cytotoxicity, immune decline, 【초록키워드】 Treatment, coronavirus disease, SARS-CoV-2, Coronavirus disease 2019, coronavirus, Risk factors, aging, Cancer, T-cells, Infection, Symptom, Infectious disease, diabetes, severe acute respiratory syndrome Coronavirus, hypertension, adverse outcomes, COPD, adverse outcome, Asymptomatic, severity of COVID-19, Patient, death, morbidity and mortality, expansion, T-cell, respiratory, underlying conditions, mortality rates, disease, pulmonary disease, chronic obstructive pulmonary disease, chronic obstructive pulmonary disease (COPD), obstructive pulmonary disease, acute respiratory syndrome, null cells, acute respiratory syndrome coronavirus, potential mechanism, acute respiratory syndrome coronavirus 2, individual, array, potential mechanisms, CD28, Severity of infection, inflammatory conditions, populations, Cell, condition, cause, senescent, chronic obstructive, 【제목키워드】 COVID19, accumulation,