Abstract
We analyzed 324,734 SARS-CoV-2 variant screening tests from France enriched with 16,973 whole-genome sequences sampled during September 1, 2021-February 28, 2022. Results showed the estimated growth advantage of the Omicron variant over the Delta variant to be 105% (95% CI 96%-114%) and that of the BA.2 lineage over the BA.1 lineage to be 49% (95% CI 44%-52%). Quantitative PCR cycle threshold values were consistent with an increased ability of Omicron to generate breakthrough infections. Epidemiologic modeling shows that, in spite of its decreased virulence, the Omicron variant can generate important critical COVID-19 activity in hospitals in France. The magnitude of the BA.2 wave in hospitals depends on the level of relaxing of control measures but remains lower than that of BA.1 in median scenarios.
Keywords: BA.1; BA.2; COVID-19; France; Omicron; PCR; SARS-CoV-2; coronavirus disease; epidemiology; genomics; mass screening; mutation; respiratory infections; severe acute respiratory syndrome coronavirus 2; vaccine-preventable diseases; variants; viruses; zoonoses.
【저자키워드】 COVID-19, coronavirus disease, severe acute respiratory syndrome coronavirus 2, viruses, respiratory infections, zoonoses, SARS-CoV-2, Mutation, Epidemiology, omicron, Genomics, variants, PCR, Mass screening, France, BA.1, vaccine-preventable diseases, BA.2, 【초록키워드】 coronavirus disease, respiratory infections, zoonoses, coronavirus, Mutation, hospital, variant, SARS-CoV-2 variant, severe acute respiratory syndrome Coronavirus, omicron, delta variant, Genomics, variants, Mass screening, Lineage, France, breakthrough infections, Omicron variant, virulence, Critical, screening test, screening tests, acute respiratory syndrome, 95% CI, acute respiratory syndrome coronavirus, acute respiratory syndrome coronavirus 2, measure, threshold value, growth advantage, Whole-genome sequence, PCR cycle, Result, analyzed, generate, median, magnitude, 【제목키워드】 modeling,