Abstract
The N-terminus domain (NTD) of the SARS-CoV-2 Omicron variant spike protien strongly induces multiple inflammatory molecules in human peripheral blood mononuclear cells, unaffected by the mutations observed in the NTD. Olverembatinib, a clinical-stage multi-kinase inhibitor, potently inhibits Omicron NTD-mediated cytokine release.
Keywords: Olverembatinib; Omicron variant; SARS-CoV-2; cytokine storm; kinase signaling.
All Keywords
【저자키워드】 SARS-CoV-2, Cytokine storm, Omicron variant, Olverembatinib, kinase signaling., 【초록키워드】 Cytokine storm, Mutation, cytokine, omicron, Peripheral blood, Omicron variant, NTD, inhibitor, Signaling, Inflammatory, Olverembatinib, mononuclear cells, domain, cytokine release, N-terminus, variant spike, inhibit, induce, the SARS-CoV-2, 【제목키워드】 Olverembatinib, mononuclear cell, cytokine release, inhibit,
【저자키워드】 SARS-CoV-2, Cytokine storm, Omicron variant, Olverembatinib, kinase signaling., 【초록키워드】 Cytokine storm, Mutation, cytokine, omicron, Peripheral blood, Omicron variant, NTD, inhibitor, Signaling, Inflammatory, Olverembatinib, mononuclear cells, domain, cytokine release, N-terminus, variant spike, inhibit, induce, the SARS-CoV-2, 【제목키워드】 Olverembatinib, mononuclear cell, cytokine release, inhibit,
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SARS-CoV-2 오미크론 변이체 스파이크 단백질의 N-말단 도메인(NTD)은 NTD에서 관찰되는 돌연변이에 영향을 받지 않고 인간 말초혈액 단핵세포에서 다중 염증 분자를 강력하게 유도합니다. 임상 단계의 다중 키나제 억제제인 올베렘바티닙은 Omicron NTD 매개 사이토카인 방출을 강력하게 억제합니다.
{{ 키워드: }} 올베렘바티닙; 오미크론 변이체; 사스 코로나바이러스 2; 사이토카인 폭풍; 키나제 신호.