Abstract
COVID-19 vaccines provide high levels of protection against severe disease and hospitalization due to severe acute respiratory syndrome-related coronavirus 2 (SARS-CoV-2) infection. Vaccination may be less effective in preventing shedding of infectious viruses from otherwise immune patients. In this study, we describe breakthrough infections and shedding of infectious viruses in convalescent hamsters without significant replication in the lower respiratory tract following reinfection by Alpha and Delta variants despite high levels of circulating antibodies in sera. Using convalescent hamsters with long-term immunity (up to 1 year) following infection by ancestral SARS-CoV-2, we can model aspects of recurring COVID-19 in the context of preexisting immunity.
Keywords: COVID-19; SARS-CoV-2; long-term immunity; variants of concern.
【저자키워드】 COVID-19, SARS-CoV-2, variants of concern., long-term immunity, 【초록키워드】 Vaccine, coronavirus, Immunity, Hospitalization, Infection, variants of concern, delta variant, coronavirus 2, variants, Replication, Severe acute respiratory syndrome, Reinfection, sera, breakthrough infections, shedding, Severe acute respiratory syndrome-related coronavirus, Breakthrough infection, hamster, convalescent, Preexisting immunity, severe disease, Lower respiratory tract, acute respiratory syndrome, severe acute respiratory syndrome-related coronavirus 2, circulating antibodies, circulating antibody, alpha and delta variants, infectious viruses, effective, less, immune patients, infectious virus, 【제목키워드】 Immunity, SARS-COV-2 infection, hamster, convalescent, upper respiratory tract, provide,