Abstract
Rapid antigen tests (RATs) for detecting severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) are widely used in the Coronavirus disease 2019 (COVID-19) pandemic caused by diverse variants. Information on the real-world performance of RATs for variants is urgently needed for decision makers. Systematic searches of the available literature and updates were conducted in PubMed, Ovid-MEDLINE, Ovid-EMBASE, CENTRAL, and KMBASE for articles evaluating the accuracy of instrument-free RATs for variants up until 14 March 2022. A bivariate random effects model was utilized to calculate pooled diagnostic values in comparison with real-time reverse transcription-polymerase chain reaction as the reference test. A total of 7562 samples from six studies were available for the meta-analysis. The overall pooled sensitivity and specificity of RATs for variants were 69.7% (95% confidence interval [CI] = 62.5% to 76.1%) and 100.0% (95% CI = 98.8% to 100.0%), respectively. When an additional 2179 samples from seven studies reporting sensitivities only were assessed, the pooled sensitivity dropped to 50.0% (95% CI = 44.0% to 55.0%). These findings suggest reassessment and monitoring of the diagnostic utility of RATs for variants, especially for the sensitivity aspect, to facilitate appropriate diagnosis and management of COVID-19 patients.
Keywords: COVID-19; SARS-CoV-2; performance; rapid antigen test; variant.
【저자키워드】 COVID-19, SARS-CoV-2, rapid antigen test, performance, Variant., 【초록키워드】 coronavirus disease, Meta-analysis, Coronavirus disease 2019, coronavirus, pandemic, variant, diagnostic, Diagnosis, severe acute respiratory syndrome Coronavirus, variants, Antigen, polymerase chain reaction, sensitivity, Rapid antigen tests, Accuracy, Sensitivity and specificity, management, Rapid, utility, COVID-19 patients, RAT, Chain Reaction, acute respiratory syndrome, reference test, 95% CI, acute respiratory syndrome coronavirus, acute respiratory syndrome coronavirus 2, 95% confidence interval, diagnostic value, RATs, real-time reverse transcription-polymerase chain reaction, CENTRAL, sensitivities, article, random effect, Seven, caused, conducted, facilitate, calculate, dropped, were assessed, 【제목키워드】 review, Test, clinical, Rapid,