Abstract
The emergence of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and its new variants reported in different countries have posed a serious threat to human health and social fabrics worldwide. In addition, these new variants hindered the efforts of vaccines and other therapeutic developments. In this review article, we explained the emergence of new variants of SARS-CoV-2, their transmission risk, mortality rate, and, more importantly, the impact of each new variant on the efficacy of the developed vaccines reported in different literature and findings. The literature reported that with the emergence of new variants, the efficacy of different vaccines is declined, hospitalization and the risk of reinfection is increased. The reports concluded that the emergence of a variant that entirely evades the immune response triggered by the vaccine is improbable. The emergence of new variants and reports of re-infections are creating a more distressing situation and therefore demands further investigation to formulate an effective therapeutic strategy.
Keywords: Infectivity; New Variants; Pathogenesis; SARS-CoV-2; Therapeutics; Vaccine.
【저자키워드】 SARS-CoV-2, Vaccine, Pathogenesis, Therapeutics, Infectivity, New Variants, 【초록키워드】 Efficacy, Vaccine, coronavirus, immune response, Pathogenesis, Hospitalization, Therapeutics, variant, risk, Transmission, severe acute respiratory syndrome Coronavirus, variants, Reinfection, Health, therapeutic, Re-infection, mortality rate, therapeutic strategy, Re-infections, acute respiratory syndrome, acute respiratory syndrome coronavirus, acute respiratory syndrome coronavirus 2, effort, variants of SARS-CoV-2, country, effective, reported, addition, explained, evade, triggered, the vaccine, New, declined, creating, 【제목키워드】 Efficacy, Vaccine, feature,