Abstract
We describe a case of prolonged COVID-19 caused by the SARS-CoV-2 Gamma variant in a fully vaccinated healthcare worker, 387 days after an infection caused by lineage B.1.1.33. Infections were confirmed by whole-genome sequencing and corroborated by the detection of neutralizing antibodies in convalescent serum samples. Considering the permanent exposure of this healthcare worker to SARS-CoV-2, the waning immunity after the first infection, the low efficacy of the inactivated vaccine at preventing COVID-19, the immune escape of the Gamma variant (VOC), and the burden of post-COVID syndrome, this individual would have benefited from an additional dose of a heterologous vaccine.
Keywords: COVID-19 breakthrough infection; SARS-CoV-2 variants; health personnel; post-acute COVID-19 syndrome; reinfection; whole-genome sequencing.
【저자키워드】 Health personnel, Reinfection, SARS-CoV-2 variants, Whole-genome sequencing., Post-acute COVID-19 syndrome, COVID-19 breakthrough infection, 【초록키워드】 COVID-19, neutralizing antibody, whole-genome sequencing, SARS-CoV-2, Efficacy, Neutralizing antibodies, VoC, variant, Infection, healthcare worker, Health personnel, Health, Immune escape, Inactivated vaccine, Lineage, Gamma, Breakthrough infection, convalescent serum, dose, heterologous vaccine, waning immunity, syndrome, B.1.1.33, caused, the SARS-CoV-2, 【제목키워드】 COVID-19, Brazil, Vaccine, variant, Gamma, syndrome, the SARS-CoV-2,