Abstract
We estimated vaccine effectiveness (VE) of the BNT162b2 (Pfizer-BioNTech, https://www.pfizer.com) booster dose against SARS-CoV-2 infection and reduction of complications (hospitalization, severe disease, and death) among breakthrough cases in persons in Israel >16 years of age for <20 weeks. VE estimates reached 96.8% (95% CI 96.0%-97.5%) for persons 16-59 years of age and 93.1% (95% CI 91.8%-94.2%) for persons >60 years of age on week 3. VE estimates remained at these levels for 8 weeks in the 16-59 age group and 11 weeks in those >60. A slow decline followed, becoming more pronounced in the last 2-3 weeks of evaluation. Estimates in the last week of evaluation were 77.6% (95% CI 68.4%-84.2%) and 61.3% (52.5%-68.4%) for persons 16-59 years and >60 years, respectively. The more pronounced VE decline coincided with rapid increase in Omicron variant activity. Rate reduction of breakthrough complications remained moderate to high throughout the evaluation.
Keywords: BNT162b2; COVID-19; Israel; Pfizer-BioNTech; SARS-CoV-2; coronavirus disease; respiratory infections; severe acute respiratory syndrome coronavirus 2; vaccines; viruses; zoonoses.
【저자키워드】 COVID-19, coronavirus disease, severe acute respiratory syndrome coronavirus 2, viruses, respiratory infections, zoonoses, SARS-CoV-2, Vaccines, BNT162b2, Israel, Pfizer-BioNTech, 【초록키워드】 coronavirus disease, respiratory infections, zoonoses, Vaccine, coronavirus, Hospitalization, SARS-COV-2 infection, variant, severe acute respiratory syndrome Coronavirus, omicron, BNT162b2, Pfizer, Effectiveness, death, Complication, age, estimate, moderate, booster dose, Pfizer-BioNTech, severe disease, reduction, acute respiratory syndrome, 95% CI, acute respiratory syndrome coronavirus, acute respiratory syndrome coronavirus 2, rapid increase, Rate, remained, reached, 【제목키워드】 of BNT162b2,