Abstract
Introduction: SARS-CoV-2 (severe acute respiratory syndrome coronavirus 2) is the virus responsible for COVID-19. It is one of the most mutating virus in the world. These mutations are responsible for the appearance of new variants, the most recent of which is Omicron (line B.1.1.529). This new variant was first identified in South Africa in November 2021. The main fear with this variant is that of an immune escape and ineffectiveness of vaccines currently available.
Objective: We studied the response of our immune system and the effectiveness of current vaccines against SARS-CoV-2 Omicron VOC.
Methods: We carried out a narrative review from 32 scientific articles from databases: MEDLINE (PubMed), Embase, BioRxiv and MedRxiv.
Results: Faced with SARS-CoV-2 Omicron VOC: The humoral immune response decreased, while the cellular immune response was preserved. The booster vaccine provided protection against symptomatic or non-symptomatic infections, transmission, and serious forms.
Conclusion: In the end, according to these data, the 3rd dose appears to be the solution to be able to defeat SARS-CoV-2 Omicron VOC. But the health authorities must not forget to insist on the primary vaccination of individuals not yet vaccinated, as well as on an “equal” distribution of vaccines against COVID-19 throughout the world.
Keywords: Cellular response; Humoral response; Neutralizing antibodies; Omicron; SRAS-CoV-2; Vaccine against COVID-19.
【저자키워드】 Neutralizing antibodies, omicron, Humoral response, SRAS-CoV-2, cellular response, Vaccine against COVID-19., 【초록키워드】 COVID-19, SARS-CoV-2, Vaccine, coronavirus, vaccination, Mutation, Neutralizing antibodies, VoC, Cellular immune response, variant, Transmission, immune system, severe acute respiratory syndrome Coronavirus, omicron, virus, variants, databases, South Africa, infections, Humoral response, Immune escape, symptomatic, Effectiveness, humoral immune response, B.1.1.529, distribution, Booster vaccine, SRAS-CoV-2, cellular response, dose, health authorities, Health authority, acute respiratory syndrome, solution, acute respiratory syndrome coronavirus, acute respiratory syndrome coronavirus 2, These data, individual, appearance, medRxiv, bioRxiv, article, forms, ineffectiveness, responsible, carried, provided, appear, preserved, 【제목키워드】 Efficacy, Vaccine, VoC, variant, Evidence, humoral, the SARS-CoV-2,