Abstract
Vaccine administration is one of the most efficient ways to control the current coronavirus disease 2019 (COVID-19) pandemic. However, the appearance of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variants can avoid the immunity generated by vaccines. Thus, in patients with a complete vaccine schedule, the infection by SARS-CoV-2 may cause severe, mild, and asymptomatic manifestations of the disease. In this case report, we describe for the first time the clinical symptoms of four patients (three symptomatic; one asymptomatic) from Santiago of Chile, with a complete vaccination schedule with two doses of CoronaVac (Sinovac Life Science) infected with the variant of interest (VOI) B.1.621 (Mu). They were compared with four unvaccinated patients, who had a higher prevalence of symptoms after infection compared to vaccinated patients. In the CoronaVac-vaccinated group, an 80-year-old patient who registered various comorbidities required Invasive mechanical ventilation for 28 days with current home medical recovery discharge. By contrast, in the unvaccinated group, a 71-year-old presented more symptoms with more than 45 days of Invasive mechanical ventilation, which continues to date, presenting greater lung damage than the vaccinated hospitalized patient. This first report evidence differences in the clinical symptomatology of patients vaccinated and non-vaccinated infected with the VOI B.1.621 (Mu) and suggest the protective effects of CoronaVac against this variant.
Keywords: COVID-19; CoronaVac; SARS-CoV-2 B.1.621 variant; case report; genomic surveillance; inactivated SARS-CoV-2 vaccine; symptoms.
【저자키워드】 COVID-19, Genomic surveillance, CoronaVac, Symptoms, Case report, Inactivated SARS-CoV-2 vaccine, SARS-CoV-2 B.1.621 variant, 【초록키워드】 coronavirus disease, SARS-CoV-2, Coronavirus disease 2019, Vaccine, coronavirus, pandemic, Hospitalized, Clinical symptoms, Immunity, mechanical ventilation, Vaccines, Genomic surveillance, variant, Infection, CoronaVac, Comorbidity, Symptom, severe acute respiratory syndrome Coronavirus, Symptoms, discharge, Case report, Prevalence, Protective effects, Asymptomatic, Patient, Mild, genomic, patients, Sinovac, B.1.621, protective effect, inactivated, Evidence, Invasive mechanical ventilation, administration, dose, manifestation, lung damage, life, Science, acute respiratory syndrome, acute respiratory syndrome coronavirus, acute respiratory syndrome coronavirus 2, clinical symptom, appearance, Registered, vaccine administration, vaccination schedule, Complete, greater, the disease, required, presenting, 【제목키워드】 report, description, the SARS-CoV-2,