Abstract
We aim to evaluate the role of single-nucleotide polymorphisms of the angiotensin-converting enzyme 2 in susceptibility to SARS-CoV-2 infection. We included 28 uninfected but highly exposed healthcare workers and 39 hospitalized patients with COVID-19. Thirty-five SNPs were rationally selected. Two variants were associated with increased risk of being susceptible to SARS-CoV-2: the minor A allele in the rs2106806 variant (OR 3.75 [95% CI 1.23-11.43]) and the minor T allele in the rs6629110 variant (OR 3.39 [95% CI 1.09-10.56]). Evaluating the role of genetic variants in susceptibility to SARS-CoV-2 infection could help identify more vulnerable individuals and suggest potential drug targets for COVID-19 patients.
Keywords: COVID-19; SARS-CoV-2; genetic variants; single-nucleotide polymorphism; susceptibility.
【저자키워드】 COVID-19, SARS-CoV-2, susceptibility, genetic variants, single-nucleotide polymorphism, 【초록키워드】 SARS-COV-2 infection, susceptibility, Genetic, variant, polymorphism, angiotensin-converting enzyme 2, healthcare worker, drug target, SNP, genetic variants, Genetic variant, single-nucleotide polymorphism, COVID-19 patients, Angiotensin-converting enzyme, angiotensin, increased risk, individual, help, T allele, uninfected, susceptible, selected, identify, evaluate, hospitalized patient, A allele, Evaluating, single-nucleotide, with COVID-19, 【제목키워드】 ACE2, susceptibility, healthcare worker, Genetic polymorphism, role,