Abstract
The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) disclose the variants of concern (VOC) including Alpha (B.1.1.7), Beta (B.1.351), Gamma (P1), Delta (B.1.617.2), and Omicron (B.1.1.529). Its spike protein (S) present on the surface of the virus is recognized by the host cell receptor, the angiotensin-2 converting enzyme (ACE2) which promotes their entry into the cell. The mutations presented by VOCs are found in RBD and the N-terminal region of S protein. Therefore, mutations occurring in RBD can modify the biological and immunogenic characteristics of the virus, such as modifying the spike affinity for ACE2, increasing the virus transmissibility, or conferring the ability to escape the immune responses. The raise of a potential new SARS-CoV-2 variant capable of evading the host defenses at the same time maintaining its fitness justifies the importance of continued genetic monitoring of the pandemic coronavirus.
Keywords: COVID-19; COVID-19 vaccination; SARS-COV-2 variants; SARS-CoV-2; viral immune escape.
【저자키워드】 COVID-19, SARS-CoV-2, COVID-19 vaccination, SARS-CoV-2 variants, viral immune escape., 【초록키워드】 ACE2, coronavirus, Mutation, S protein, VoC, B.1.351, Genetic, variant, variants of concern, Delta, B.1.617.2, severe acute respiratory syndrome Coronavirus, omicron, virus, variants, Spike protein, Characteristics, Immune escape, SARS-CoV-2 variants, B.1.1.7, RBD, immune responses, VOCs, Gamma, Alpha, Beta, B.1.1.529, pandemic coronavirus, angiotensin, host cell, acute respiratory syndrome, acute respiratory syndrome coronavirus, acute respiratory syndrome coronavirus 2, host cell receptor, immunogenic, Defense, N-terminal, virus transmissibility, Host, Cell, angiotensin-2 converting enzyme, new SARS-CoV-2, raise, promote, modify, 【제목키워드】 characterization,