Abstract
Recently, Covid-19 vaccine effectiveness has decreased especially against mild disease due to emergence of the Delta variant and waning protection. In this register-based study among healthcare workers in Finland, the vaccine effectiveness of two-dose mRNA vaccine series against SARS-CoV-2 infection decreased from 82% (95% CI 79-85%) 14-90 days after vaccination to 53% (43-62%) after 6 months. Similar trend was observed for other series. Waning was not observed against Covid-19 hospitalization. These results facilitate decision-making of booster doses for healthcare workers.
Keywords: Covid-19 hospitalization; Healthcare workers; SARS-CoV-2 infection; Vaccine effectiveness; Waning.
All Keywords
【저자키워드】 Healthcare workers, SARS-COV-2 infection, COVID-19 hospitalization, vaccine effectiveness, waning, 【초록키워드】 SARS-CoV-2, Vaccine, vaccination, Healthcare workers, Hospitalization, mRNA vaccine, SARS-COV-2 infection, delta variant, healthcare worker, healthcare, Effectiveness, Mild, COVID-19 hospitalization, Decision-making, disease, booster dose, Mild disease, booster doses, 95% CI, facilitate, the vaccine, 【제목키워드】 Vaccine, healthcare worker, Effectiveness,
【저자키워드】 Healthcare workers, SARS-COV-2 infection, COVID-19 hospitalization, vaccine effectiveness, waning, 【초록키워드】 SARS-CoV-2, Vaccine, vaccination, Healthcare workers, Hospitalization, mRNA vaccine, SARS-COV-2 infection, delta variant, healthcare worker, healthcare, Effectiveness, Mild, COVID-19 hospitalization, Decision-making, disease, booster dose, Mild disease, booster doses, 95% CI, facilitate, the vaccine, 【제목키워드】 Vaccine, healthcare worker, Effectiveness,
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최근에는 Delta 변이의 출현과 방어력 약화로 인해 특히 경증에 대한 코로나19 백신의 효과가 감소하고 있다. 핀란드 의료 종사자를 대상으로 한 이 등록 기반 연구에서 SARS-CoV-2 감염에 대한 2회 접종 mRNA 백신 시리즈의 백신 효과는 백신 접종 후 14-90일에 82%(95% CI 79-85%)에서 53일로 감소했습니다. 6개월 후 %(43-62%). 다른 시리즈에서도 비슷한 경향이 관찰되었습니다. 코로나19 입원에 대한 완화는 관찰되지 않았다. 이러한 결과는 의료 종사자를 위한 추가 접종량의 의사 결정을 용이하게 합니다.
{{ 키워드: }} 코로나19 입원; 의료 종사자; SARS-CoV-2 감염; 백신 효과; 약해지고 있다.