Abstract
Functional immunity (defined here as serum neutralising capacity) critically contributes to conferring protection against SARS-CoV-2 infection and severe COVID-19. This cross-sectional analysis of a prospective, population-based cohort study included 1,894 randomly-selected 16 to 99-year-old participants from two Swiss cantons in March 2022. Of these, 97.6% (95% CI: 96.8-98.2%) had anti-spike IgG antibodies, and neutralising capacity was respectively observed for 94%, 92% and 88% against wild-type SARS-CoV-2, Delta and Omicron variants. Studying functional immunity to inform and monitor vaccination campaigns is crucial.
Keywords: SARS-CoV-2; neutralising activity; seroprevalence; variants of concern.
【저자키워드】 SARS-CoV-2, Seroprevalence, variants of concern., Neutralising activity, 【초록키워드】 vaccination, severe COVID-19, Immunity, SARS-COV-2 infection, Seroprevalence, variants of concern, Delta, omicron, Omicron variants, variants, cohort study, serum, population-based cohort, 95% CI, cross-sectional analysis, participant, wild-type SARS-CoV-2, anti-spike IgG antibodies, MONITOR, neutralising, defined, functional, contribute, 【제목키워드】 Immunity, Delta, omicron, General population, Switzerland, booster,