Influenza virus and coronavirus epidemics or pandemics have occurred in succession worldwide throughout the early 21st century. These epidemics or pandemics pose a major threat to human health. Here, we outline a critical role of the host cell protease TMPRSS2 in influenza virus and coronavirus infections and highlight an antiviral therapeutic strategy targeting TMPRSS2. Highlights • The structure and physiological function of TMPRSS2. • TMPRSS2 is involved in proteolytic activation of influenza virus and coronavirus. • Development of therapeutics targeting TMPRSS2.
All Keywords
【저자키워드】 TMPRSS2, coronavirus, Therapeutics, Influenza virus, TMPRSS2, transmembrane protease, serine 2, PAI-1, plasminogen activator inhibitor 1, CoV, coronavirus, FDA, Food and Drug Administration, HAT, Human airway trypsin-like protease, HGF, Hepatocyte Growth Factor, ARE, androgen receptor element, AEBSF, 4-(2-Aminomethyl)benzenesulfonyl fluoride hydrochloride, BHH, Bromhexine hydrochloride, DESC1, serine protease DESC1, EST, (2S,3S)-trans-Epoxysuccinyl-L-leucylamido-3-methylbutane ethyl ester, HAI-2, hepatocyte growth factor activator inhibitor 2, IFITM, Interferon-induced transmembrane protein, MMP-2, matrix metalloproteinase-2, MSPL, transmembrane protease, serine 13, PAR-2, protease activated receptor 2, PPMO, peptide-conjugated phosphorodiamidate morpholino oligomer, RBS, receptor binding subdomain, THE, human tracheal epithelial, TMPRSS4, transmembrane protease serine 4, TTSP, type II transmembrane serine protease, vRNPs, viral ribonucleoproteins,
【저자키워드】 TMPRSS2, coronavirus, Therapeutics, Influenza virus, TMPRSS2, transmembrane protease, serine 2, PAI-1, plasminogen activator inhibitor 1, CoV, coronavirus, FDA, Food and Drug Administration, HAT, Human airway trypsin-like protease, HGF, Hepatocyte Growth Factor, ARE, androgen receptor element, AEBSF, 4-(2-Aminomethyl)benzenesulfonyl fluoride hydrochloride, BHH, Bromhexine hydrochloride, DESC1, serine protease DESC1, EST, (2S,3S)-trans-Epoxysuccinyl-L-leucylamido-3-methylbutane ethyl ester, HAI-2, hepatocyte growth factor activator inhibitor 2, IFITM, Interferon-induced transmembrane protein, MMP-2, matrix metalloproteinase-2, MSPL, transmembrane protease, serine 13, PAR-2, protease activated receptor 2, PPMO, peptide-conjugated phosphorodiamidate morpholino oligomer, RBS, receptor binding subdomain, THE, human tracheal epithelial, TMPRSS4, transmembrane protease serine 4, TTSP, type II transmembrane serine protease, vRNPs, viral ribonucleoproteins,