Abstract
The human immune system protects the body against invasive organisms and kicks into a hyperactive mode in COVID-19 patients, particularly in those who are critically sick. Therapeutic regimens directed at the hyperactive immune system have been found to be effective in the treatment of patients with COVID-19. An evolving potential treatment option is therapy with mesenchymal stem cells (MSCs) due to their regenerative and reparative ability in epithelial cells. Clinical trials have reported the safe usage of MSC therapy. Systemic effects of MSC treatment have included a reduction in pro-inflammatory cytokines and a decrease in the levels of CRP, IL-6, and lactase dehydrogenase, which function as independent biomarkers for COVID-19 mortality and respiratory failure.
Keywords: COVID-19; biomarkers; clinical immunology; endothelitis; mesenchymal stem cells.
【저자키워드】 COVID-19, Biomarkers, clinical immunology, Endothelitis, mesenchymal stem cells., 【초록키워드】 Treatment, stem cells, therapy, Biomarker, Biomarkers, Cytokines, Respiratory failure, Trial, IL-6, clinical trials, CRP, Mesenchymal stem cells, MSCs, immune system, systemic effects, clinical, epithelial cells, pro-inflammatory cytokines, regenerative, COVID-19 patients, Endothelitis, MSC, Human immune system, COVID-19 mortality, Safe, systemic, regimen, stem cell, MSC therapy, potential treatment option, pro-inflammatory cytokine, organism, Effect, effective, decrease, invasive, independent, PROTECT, reported, sick, reduction in, patients with COVID-19, 【제목키워드】 Treatment, immune response, mesenchymal stem cell, patients with COVID-19,