[저자] Brendan Flannery, Jessie R Chung, Arnold S Monto, Emily T Martin, Edward A Belongia, Huong Q McLean, Manjusha Gaglani, Kempapura Murthy, Richard K Zimmerman, Mary Patricia Nowalk, Michael L Jackson, Lisa A Jackson, Melissa A Rolfes, Sarah Spencer, Alicia M Fry,
US Flu VE Investigators
PetrieJoshua GMaloshRyan EMcSpaddenE JSegaloffHannah EChengCaroline KTrusconRachelJohnsonEmileighLameratoLois EIvacicLynn CKingJennifer PMeeceJennifer KPalmquistMadalyn MGuzinskiSherri ARobertsonAnneKossieAshleySmithMichaelHoelscherVanessaClipperLydiaWalkerKimberleyVolzMarcusRaoArundhatiFaderRobertMunoz-MaldonadoYolandaReisMichaelWilliamsJohn VBalasubramaniGoundappa KReisEvelyn CEngHeatherFordSamanthaBearTodd MRicciEdmund MHickeyRobert WMoehlingKrissy KRaviottaJonathan MSaxTheresa MSusickMichaelJohnsonMonikaAzrakRoseBermanLaShondraFoustAngieSessionsWendyDaSilvaJulianaStarkThomasBarnesJohn
, Joshua G Petrie, Ryan E Malosh, E J McSpadden, Hannah E Segaloff, Caroline K Cheng, Rachel Truscon, Emileigh Johnson, Lois E Lamerato, Lynn C Ivacic, Jennifer P King, Jennifer K Meece, Madalyn M Palmquist, Sherri A Guzinski, Anne Robertson, Ashley Kossie, Michael Smith, Vanessa Hoelscher, Lydia Clipper, Kimberley Walker, Marcus Volz, Arundhati Rao, Robert Fader, Yolanda Munoz-Maldonado, Michael Reis, John V Williams, Goundappa K Balasubramani, Evelyn C Reis, Heather Eng, Samantha Ford, Todd M Bear, Edmund M Ricci, Robert W Hickey, Krissy K Moehling, Jonathan M Raviotta, Theresa M Sax, Michael Susick, Monika Johnson, Rose Azrak, LaShondra Berman, Angie Foust, Wendy Sessions, Juliana DaSilva, Thomas Stark, John Barnes
[Category] Fulltext, 신종인플루엔자,
[Source] PMC
Abstract Background In recent influenza seasons, the effectiveness of inactivated influenza vaccines against circulating A(H3N2) virus has been lower than against A(H1N1)pdm09 and B viruses, even when circulating viruses remained antigenically similar to vaccine components. Methods During the 2016–2017 influenza season, vaccine effectiveness (VE) across age groups and vaccine types was examined among outpatients with acute respiratory illness at 5 US sites using a test-negative design that compared the odds of vaccination among reverse transcription polymerase chain reaction–confirmed influenza positives and negatives. Results Among 7083 enrollees, 1342 (19%) tested positive for influenza A(H3N2), 648 (9%) were positive for influenza B (including B/Yamagata, n = 577), and 5040 (71%) were influenza negative. Vaccine effectiveness was 40% (95% confidence interval [CI], 32% to 46%) against any influenza virus, 33% (95% CI, 23% to 41%) against influenza A(H3N2) viruses, and 53% (95% CI, 43% to 61%) against influenza B viruses. Conclusions The 2016–2017 influenza vaccines provided moderate protection against any influenza among outpatients but were less protective against influenza A(H3N2) viruses than B viruses. Approaches to improving effectiveness against A(H3N2) viruses are needed. The 2016–2017 influenza vaccines provided moderate protection against any influenza among outpatients but were less protective against influenza A(H3N2) viruses than B viruses.
All Keywords
【저자키워드】 influenza vaccine, vaccine effectiveness,