Severe acute respiratory syndrome (SARS) is a highly contagious viral respiratory illness. This illness is spurred on by a coronavirus known as SARS-associated coronavirus (SARS-CoV). SARS was first detected in Asia in late February 2003. The genome of this virus is very similar to the SARS-CoV-2. Therefore, the study of SARS-CoV disease and the identification of effective drugs to treat this disease can be new clues for the treatment of SARS-Cov-2. This study aimed to discover novel potential drugs for SARS-CoV disease in order to treating SARS-Cov-2 disease based on a novel systems biology approach. To this end, gene co-expression network analysis was applied. First, the gene co-expression network was reconstructed for 1441 genes, and then two gene modules were discovered as significant modules. Next, a list of miRNAs and transcription factors that target gene co-expression modules’ genes were gathered from the valid databases, and two sub-networks formed of transcription factors and miRNAs were established. Afterward, the list of the drugs targeting obtained sub-networks’ genes was retrieved from the DGIDb database, and two drug-gene and drug-TF interaction networks were reconstructed. Finally, after conducting different network analyses, we proposed five drugs, including FLUOROURACIL , CISPLATIN , SIROLIMUS , CYCLOPHOSPHAMIDE , and METHYLDOPA, as candidate drugs for SARS-CoV-2 coronavirus treatment. Moreover, ten miRNAs including miR-193b, miR-192, miR-215, miR-34a, miR-16, miR-16, miR-92a, miR-30a, miR-7, and miR-26b were found to be significant miRNAs in treating SARS-CoV-2 coronavirus.
【저자키워드】 Computational models, Gene ontology, Microarrays, Drug screening, 【초록키워드】 Treatment, coronavirus, SARS-CoV, Genome, miRNA, drugs, SARS-CoV-2 coronavirus, Respiratory illness, Systems biology, drug, virus, database, effective drugs, Asia, Severe acute respiratory syndrome, miRNAs, Viral, respiratory, disease, Sirolimus, Interaction, gene co-expression network, Analysis, Cyclophosphamide, transcription factor, transcription factors, target gene, cisplatin, SARS-CoV-2 disease, acute respiratory syndrome, METHYLDOPA, FLUOROURACIL, treat, list, candidate drugs, contagious, Genes, approach, FIVE, co-expression, applied, analyses, reconstructed, viral respiratory, drugs targeting, candidate drug, effective drug, retrieved, the SARS-CoV-2, 【제목키워드】 Drug repurposing, SARS-CoV-2, Analysis,