Highlights • The mean incubation period is 2-14 days, and the basic reproduction number is 2.24-3.58. • COVID-19 infection should be diagnosed clinically with typical respiratory syndromes coupled with recent exposure. • Chest computerized tomography (CT) could facilitate early diagnosis. • Public health measures, such as isolation, quarantine, social distancing and community containment, can curb COVID-19. • Clinical trials assessing antivirals, chloroquine, hydroxychloroquine, glucocorticoids, convalescent plasma transfusion against COVID-19. In December 2019, the outbreak of the novel coronavirus disease (COVID-19) in China spread worldwide, becoming an emergency of major international concern. SARS-CoV-2 infection causes clusters of severe respiratory illness similar to severe acute respiratory syndrome coronavirus. Human-to-human transmission via droplets, contaminated hands or surfaces has been described, with incubation times of 2-14 days. Early diagnosis, quarantine, and supportive treatments are essential to cure patients. This paper reviews the literature on all available information about the epidemiology, diagnosis, isolation and treatments of COVID-19. Treatments, including antiviral agents, chloroquine and hydroxychloroquine, corticosteroids, antibodies, convalescent plasma transfusion and vaccines, are discussed in this article. In addition, registered trials investigating treatment options for COVID-19 infection are listed.
【저자키워드】 COVID-19, pandemic, Diagnosis, Remdesivir, clinical trials, Isolation,