Both feline coronavirus (FCoV) and SARS-CoV-2 are coronaviruses that infect cats and humans, respectively. However, cats have been shown to be susceptible to SARS-CoV-2, and FCoV also had been shown to infect human. To elucidate the relationship between FCoV and SARS-CoV-2, we highlight the main characteristics of the genome, the receptor usage, and the correlation of the receptor-binding domain (RBD) of spike proteins in FCoV and SARS-CoV-2. It is demonstrated that FCoV and SARS-CoV-2 are closely related to the main characteristics of the genome, receptor usage, and RBD of spike proteins with similar furin cleavage sites. In particular, the affinity of the conserved feline angiotensin-converting enzyme 2 (fACE2) receptor to the RBD of SARS-CoV-2 suggests that cats are susceptible to SARS-CoV-2. In addition, cross-species of coronaviruses between cats and humans or other domesticated animals are also discussed. This review sheds light on cats as potential intermediate hosts for SARS-CoV-2 transmission, and cross-species transmission or zoonotic infection of FCoV and SARS-CoV-2 between cats and humans was identified.
【저자키워드】 SARS-CoV-2, ACE2, angiotensin-converting enzyme 2, RBD, receptor-binding domain, Spike protein, Receptor-binding domain, receptor, NTD, N-terminal domain, Feline coronavirus, CTD, C-terminal domain, ORFs, open reading frames, SARS-CoV-2, severe acute respiratory syndrome 2, Ang, angiotensin, HCoV-229E, human coronavirus 229E, FIPV, feline infectious peritonitis virus, PRCV, porcine respiratory coronavirus, TGEV, transmissible gastroenteritis virus, FCoV, Feline coronavirus, NP, nucleocapsid protein, FECV, feline enteric coronavirus, CCoV, canine coronavirus, fAPN, feline aminopeptidase-N, cry-EM, cryo-electron microscopy, fDC-SIGN, feline dendritic cell-specific intercellular adhesion molecule grabbing non-integrin, PDCoV, porcine delta coronavirus, UCD, University of California, Davis,