Graphical abstract The coronavirus disease 2019 (COVID-19) quickly swept over the world, becoming one of the most devastating outbreaks in human history. Being the first pandemic in the post-genomic era, advancements in genomics contributed significantly to scientific understanding and public health response to COVID-19. Genomic technologies have been employed by researchers all over the world to better understand the biology of SARS-CoV-2 and its origin, genomic diversity, and evolution. Worldwide genomic resources have greatly aided in the investigation of the COVID-19 pandemic. The pandemic has ushered in a new era of genomic surveillance, wherein scientists are tracking the changes of the SARS-CoV-2 genome in real-time at the international and national levels. Availability of genomic and proteomic information enables the rapid development of molecular diagnostics and therapeutics. The advent of high-throughput sequencing and genome editing technologies led to the development of modern vaccines. We briefly discuss the impact of genomics in the ongoing COVID-19 pandemic in this review.
【저자키워드】 COVID-19, SARS-CoV-2, Genomic surveillance, SARS-CoV-2, Severe acute respiratory syndrome coronavirus 2, RBD, receptor-binding domain, Genomics, reverse vaccinology, VOC, variants of concern, MERS-CoV, Middle East respiratory syndrome coronavirus, RdRp, RNA-dependent RNA polymerase, CRISPR, Clustered Regularly Interspaced Short Palindromic Repeats, NSP, non-structural protein, UTR, untranslated region, WHO, World Health Organization, ORF, open reading frame, RTC, replication-transcription complex, TMPRSS2, Transmembrane Protease Serine 2, GISAID, Global Initiative on Sharing All Influenza Data, COVID-19, coronavirus disease, ICTV, International Committee on Taxonomy of Viruses, ICMR, Indian Council of Medical Research, NGS, Next-Generation Sequencing, PRF, programmed -1 ribosomal frameshifting, ACE2, Angiotensin-Converting Enzyme – 2, CSIR, Council Of Scientific And Industrial Research, PANGOLIN, Phylogenetic Assignment of Named Global Outbreak Lineages, TMEM106B, Transmembrane protein 106B, VOI, Variants of Interest,