Background/aim The aim of this study is to evaluate the epidemiological and clinical characteristics and parameters that determined the clinical course and prognosis of the COVID-19 patients admitted to Ankara City Hospital during the first month of the pandemic in Turkey. Materials and methods SARS-CoV-2 PCR positive patients who were hospitalized between March 10 and April 10, 2020 were included. Results Among 222 patients, mean age was higher in severe acute respiratory illness (SARI)/critical disease group (P < 0.001). Median time from illness onset to admission and presence of comorbidity, especially coronary artery disease and chronic obstructive pulmonary disease, were significantly higher in the SARI/critical disease group (P < 0.05). Cough and fever were the most common symptoms, while anosmia and loss of taste were observed in 8.6% and 7.7% patients, respectively. The mortality rate was 5.4%. A high neutrophil/lymphocyte ratio; low lymphocyte, monocyte, and platelet count; elevated liver enzymes; low GFR; and high levels of muscle enzymes, ferritin, and IL-6 on admission were found to be associated with SARI/critical disease (P < 0.05). Bilateral ground-glass opacity and patchy infiltration were more frequently seen in the SARI/critical disease group (P < 0.001). Patients older than 65 years had an 8-fold increased risk for development of SARI/critical disease. Conclusion This cohort study regarding COVID-19 cases in Turkey reveals that older age, presence of comorbidity, bilateral infiltration on CT, high neutrophil/lymphocyte ratio, low monocyte and platelet count, elevated liver enzymes, low GFR, high levels of muscle enzymes, and high levels of ferritin and IL-6 on admission are predictors of SARI and severe disease.
【저자키워드】 COVID-19, Mortality, Prognosis, Epidemiology, IL-6, Turkey, 【초록키워드】 pandemic, Hospitalized, Prognosis, Clinical characteristics, IL-6, neutrophil, Comorbidity, ferritin, Turkey, Symptoms, cohort study, Anosmia, monocyte, Coronary artery disease, lymphocyte, ground-glass opacity, Clinical course, Fever, Older age, Platelet, age, epidemiological, mortality rate, predictor, Taste, respiratory, Enzymes, disease, Admission, liver, patients, COVID-19 patients, Critical disease, pulmonary disease, Platelet count, liver enzymes, infiltration, chronic obstructive pulmonary disease, severe disease, COVID-19 cases, SARS-CoV-2 PCR, COVID-19 patient, obstructive pulmonary disease, Coronary artery, on admission, Older, elevated liver enzymes, acute respiratory illness, increased risk, median time, COVID-19 case, city, loss of taste, material, illness onset, SARI, parameter, Result, evaluate, elevated, significantly higher, reveal, positive patient, GFR, chronic obstructive, Bilateral, patchy, 【제목키워드】 pandemic,