Abstract
Although direct kidney infection by SARS-CoV-2 remains controversial, a study based largely on autopsies shows increased tubulointerstitial fibrosis in patients with COVID-19 and suggests direct kidney infection. Moreover, in human kidney organoids, SARS-CoV-2 infection upregulates several pro-fibrotic and pro-inflammatory pathways.
All Keywords
【초록키워드】 SARS-CoV-2, SARS-COV-2 infection, fibrosis, Autopsy, organoids, Pathways, Autopsies, pro-inflammatory, human kidney, kidney infection, patients with COVID-19, pro-fibrotic, upregulate, 【제목키워드】 SARS-CoV-2, Injury, Potential,
【초록키워드】 SARS-CoV-2, SARS-COV-2 infection, fibrosis, Autopsy, organoids, Pathways, Autopsies, pro-inflammatory, human kidney, kidney infection, patients with COVID-19, pro-fibrotic, upregulate, 【제목키워드】 SARS-CoV-2, Injury, Potential,
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SARS-CoV-2에 의한 직접적인 신장 감염은 여전히 논란의 여지가 있지만, 주로 부검을 기반으로 한 연구는 COVID-19 환자에서 세뇨관간질 섬유증 증가를 보여주며 직접적인 신장 감염을 시사합니다. 더욱이, 인간 신장 오르가노이드에서 SARS-CoV-2 감염은 몇 가지 전섬유화 및 전염증성 경로를 상향조절합니다.