During the ongoing global COVID-19 pandemic disease, like several countries, Romania experienced a multiwaves pattern over more than two years. The spreading pattern of SARS-CoV-2 pathogens in the Bucharest, capital of Romania is a multi-factorial process involving among other factors outdoor environmental variables and viral inactivation. Through descriptive statistics and cross-correlation analysis applied to daily time series of observational and geospatial data, this study aims to evaluate the synergy of COVID-19 incidence and lethality with air pollution and radon under different climate conditions, which may exacerbate the coronavirus’ effect on human health. During the entire analyzed period 1 January 2020–21 December 2021, for each of the four COVID-19 waves were recorded different anomalous anticyclonic synoptic meteorological patterns in the mid-troposphere, and favorable stability conditions during fall-early winter seasons for COVID-19 disease fast-spreading, mostly during the second, and the fourth waves. As the temporal pattern of airborne SARS-CoV-2 and its mutagen variants is affected by seasonal variability of the main air pollutants and climate parameters, this paper found: 1) the daily outdoor exposures to air pollutants (particulate matter PM2.5 and PM10, nitrogen dioxide-NO 2 , sulfur dioxide-SO 2 , carbon monoxide-CO) and radon – 222 Rn, are directly correlated with the daily COVID-19 incidence and mortality, and may contribute to the spread and the severity of the pandemic; 2) the daily ground ozone-O 3 levels, air temperature, Planetary Boundary Layer height, and surface solar irradiance are anticorrelated with the daily new COVID-19 incidence and deaths, averageingful for spring-summer periods. Outdoor exposure to ambient air pollution associated with radon is a non-negligible driver of COVID-19 transmission in large metropolitan areas, and climate variables are risk factors in spreading the viral infection. The findings of this study provide useful information for public health authorities and decision-makers to develop future pandemic diseases strategies in high polluted metropolitan environments. Graphical abstract Image 1
【저자키워드】 COVID-19, Coronavirus disease 2019, MERS-CoV, Middle East respiratory syndrome coronavirus, NO2, PM10, SO2, co, O3, NASA, Climate variables, Synoptic atmospheric circulation, Reanalysis NCEP/NCAR PSD, CO, carbon monoxide, PM, particulate matter, COVID-19 viral infection, Air pollutants: PM2.5, Radon (222Rn), SARS-CoV-2, Severe Outdoor Respiratory Syndrome Coronavirus 2, SARS-CoV, Severe Outdoor Respiratory Syndrome Coronavirus, DNC-Daily, New COVID-19 positive cases, DND, Daily New COVID-19 Deaths, PM1(1 μm), PM2.5 (2.5 μm) and PM10(10.0 μm) diameter, O3, Ozone, NO2, Nitrogen dioxide, SO2, Sulfur dioxide, 222Rn, Radon, PBL, Planetary Boundary Layer height, T, Air temperature, RH, Air relative humidity, w, Wind speed intensity, SI, Surface solar global irradiance, NOAA, National Oceanic and Atmospheric Administration U.S.A,