Graphical abstract COVID-19 caused by SARS-CoV-2 is the latest pandemic which has thrown the world into an unprecedented social and economic uncertainties along with huge loss to humanity. Identification of the host factors regulating the replication of SARS-CoV-2 in human host may help in the development of novel anti-viral therapies to combat the viral infection and spread. Recently, some research groups used genome-wide CRISPR/Cas screening to identify the host factors critical for the SARS-CoV-2 replication and infection. A comparative analysis of these significant host factors (p < 0.05) identified fifteen proteins common in these studies. Apart from ACE2 (receptor for SARS-CoV-2 attachment), other common host factors were CSNK2B, GDI2, SLC35B2, DDX51, VPS26A, ARPP-19, C1QTNF7, ALG6, LIMA1, COG3, COG8, BCOR, LRRN2 and TLR9. Additionally, viral interactome of these host factors revealed that many of them were associated with several SARS-CoV-2 proteins as well. Interestingly, some of these host factors have already been shown to be critical for the pathogenesis of other viruses suggesting their crucial role in virus-host interactions. Here, we review the functions of these host factors and their role in other diseases with special emphasis on viral diseases.
【저자키워드】 COVID-19, SARS-CoV-2, host factors, ACE2, angiotensin-converting enzyme 2, CRISPR, RSV, respiratory syncytial virus, DENV, dengue virus, Viral diseases, TMPRSS2, Transmembrane Protease Serine 2, IAV, influenza A virus, COVID-19, coronavirus disease 19, HIV-1, human immunodeficiency virus 1, HCC, hepatocellular carcinoma, CHIKV, Chikungunya virus, HCV, hepatitis C virus, PP2A, Protein phosphatase 2A, TLR, toll-like receptors, TMV, Tobacco Mosaic Virus, RRA, robust-rank aggregation, CSNK2B, casein kinase 2 subunit beta, VACV, vaccinia virus, HPV, Human Papilloma Virus, HSV-1, Herpes Simplex Virus-1, GDI2, GDP dissociation inhibitor beta, VSV, Vesicular Somatitis Virus, SLC35B2, solute carrier family 35 member B2, SBV, Schmallenberg virus, DDX, DEAD-box RNA helicase, VPS, vacuolar protein sorting, TBSV, Tomato bushy stunt virus, CIRV, Carnation Italian ringspot virus, ARPP-19, cyclic adenosine monophosphate-regulated phosphoprotein 19, C1QTNF7, C1q and tumor necrosis factor-related protein 7, CTRP, C1q complement/TNF-related protein, SNPs, single nucleotide polymorphisms, ALG, Alpha-1,3-glucosyltransferase, CDGS, carbohydrate-deficient glycoprotein syndrome, CDG1C, congenital disorder of N-linked glycosylation type 1C, LIMA-1, LIM domain and actin binding-1, EPLIN, epithelial protein lost in neoplasm, SREBP3, sterol regulatory element binding protein 3, COG, conserved oligomeric Golgi, BCOR, BCL6 interacting co-repressor, HDACS, histone deacetylases, EBV, Epstein–Barr virus, LRRN2, leucine-rich repeat neuronal protein 2,