[저자] Will Fischer, Elena E. Giorgi, Srirupa Chakraborty, Kien Nguyen, Tanmoy Bhattacharya, James Theiler, Pablo A. Goloboff, Hyejin Yoon, Werner Abfalterer, Brian T. Foley, Houriiyah Tegally, James Emmanuel San, Tulio de Oliveira,
Network for Genomic Surveillance in South Africa (NGS-SA)WilkinsonEduanMsomiNokukhanyaIranzadehArashFonsecaVagnerDoolabhDeelanMlisanaKolekavon GottbergAnneWalazaSibongileAllamMushalIsmailArshadMohaleThaboGlassAllison J.EngelbrechtSusanVan ZylGertPreiserWolfgangPetruccioneFrancescoSigalAlexHardieDianaMaraisGertHsiaoMarvinKorsmanStephenDaviesMary-AnnTyersLynnMudauInnocentYorkDenisMasloCarolineGoedhalsDominiqueAbrahamsShareefLaguda-AkingbaOluwakemiAlisoltani-DehkordiArghavanGodzikAdamWibmerConstantinos KurtSewellBryan TrevorLourençoJoséPondSergei L. KosakovskyWeaverStevenGiovanettiMartaAlcantaraLuiz Carlos JuniorMartinDarrenBhimanJinal N.WilliamsonCarolyn
, Eduan Wilkinson, Nokukhanya Msomi, Arash Iranzadeh, Vagner Fonseca, Deelan Doolabh, Koleka Mlisana, Anne von Gottberg, Sibongile Walaza, Mushal Allam, Arshad Ismail, Thabo Mohale, Allison J. Glass, Susan Engelbrecht, Gert Van Zyl, Wolfgang Preiser, Francesco Petruccione, Alex Sigal, Diana Hardie, Gert Marais, Marvin Hsiao, Stephen Korsman, Mary-Ann Davies, Lynn Tyers, Innocent Mudau, Denis York, Caroline Maslo, Dominique Goedhals, Shareef Abrahams, Oluwakemi Laguda-Akingba, Arghavan Alisoltani-Dehkordi, Adam Godzik, Constantinos Kurt Wibmer, Bryan Trevor Sewell, José Lourenço, Sergei L. Kosakovsky Pond, Steven Weaver, Marta Giovanetti, Luiz Carlos Junior Alcantara, Darren Martin, Jinal N. Bhiman, Carolyn Williamson, Sandrasegaram Gnanakaran, Bette Korber
[Category] MERS, SARS,
[Article Type] Review
[Source] PMC
Humanity is currently facing the challenge of two devastating pandemics caused by two very different RNA viruses: HIV-1, which has been with us for decades, and SARS-CoV-2, which has swept the world in the course of a single year. The same evolutionary strategies that drive HIV-1 evolution are at play in SARS-CoV-2. Single nucleotide mutations, multi-base insertions and deletions, recombination, and variation in surface glycans all generate the variability that, guided by natural selection, enables both HIV-1’s extraordinary diversity and SARS-CoV-2’s slower pace of mutation accumulation. Even though SARS-CoV-2 diversity is more limited, recently emergent SARS-CoV-2 variants carry Spike mutations that have important phenotypic consequences in terms of both antibody resistance and enhanced infectivity. We review and compare how these mutational patterns manifest in these two distinct viruses to provide the variability that fuels their evolution by natural selection. Mankind is currently struggling with two pandemics driven by RNA viruses, HIV-1 and SARS-CoV-2. Here we compare how evolutionary strategies for diversification manifest in these two viruses, and discuss how this relates to their origins, the trajectory of their continuing global diversification, and the implications for future vaccines.
All Keywords
【저자키워드】 Evolution, SARS-CoV-2, glycosylation, Immune escape, HIV-1, Recombination, insertions and deletions,