Introduction: Lung injury is common in COVID-19 patients. The severity of lung injury appears to be reflected in serum KL-6, a glycoprotein expressed on type II alveolar epithelium. This study aims to assess the role of serum KL-6 in reflecting the severity of lung injury in COVID-19 patients. Methods: A systematic search was conducted in Scopus, PubMed, Wiley Online Library, and ProQuest. Articles were screened based on several eligibility criteria and assessed for study quality using NOS. Results: This systematic review included four studies involving a total of 151 adult COVID-19 patients. Pooled analysis revealed that serum KL-6 was significantly higher in severe patients (SMD = 1.16; 95% CI = 0.69–1.63) with moderately high pooled sensitivity (79%; 95% CI = 61–91%) and specificity (86%; 95% CI = 72–95%). Conclusion: High serum KL-6 may depict more severe lung injury in COVID-19 patients with moderately high sensitivity and specificity.
【저자키워드】 COVID-19, Biomarker, Infectious disease, Krebs von den Lungen-6, Lung injury, 【초록키워드】 severity, systematic review, Lung injury, serum, sensitivity, specificity, Sensitivity and specificity, glycoprotein, eligibility criteria, Severe patient, COVID-19 patients, Analysis, Injury, COVID-19 patient, on type, severe patients, 95% CI, library, article, ProQuest, adult COVID-19 patients, alveolar epithelium, SMD, severe lung injury, conducted, screened, appear, reflected, expressed, significantly higher, NOS, 【제목키워드】 review,