Abstract
With the outbreak of the coronavirus disease 2019 (COVID-19) pandemic, the importance of vaccines in epidemic prevention and public health has become even more obvious than ever. However, the emergence of multiple severe acute respiratory syndrome coronavirus 2 variants worldwide has raised concerns about the effectiveness of current COVID-19 vaccines. Here, we review the characteristics of COVID-19 vaccine candidates in five platforms and the latest clinical trial results of them. In addition, we further discuss future directions for the research and development of the next generation of COVID-19 vaccines. We also summarize the serious adverse events reported recently after the large-scale vaccination with the current COVID-19 vaccines, including the thromboembolism caused by the AstraZeneca and Johnson & Johnson vaccines.
【초록키워드】 COVID-19, coronavirus disease, public health, Coronavirus disease 2019, Vaccine, coronavirus, COVID-19 vaccine, vaccination, clinical trial, pandemic, Vaccines, variant, research and development, COVID-19 vaccines, Epidemic, Characteristics, outbreak, Research, Thromboembolism, Effectiveness, platform, AstraZeneca, Serious Adverse Events, Serious Adverse Event, acute respiratory syndrome, acute respiratory syndrome coronavirus, acute respiratory syndrome coronavirus 2, candidate, vaccine candidates, Johnson & Johnson, FIVE, caused, reported, addition, raised, 【제목키워드】 potential risk,