Abstract
Since the start of SARS-CoV-2 pandemic, children aged ≤ 12 years have always been defined as underrepresented in terms of SARS-CoV-2 infections’ frequency and severity. By correlating SARS-CoV-2 transmission dynamics with clinical and virological features in 612 SARS-CoV-2 positive patients aged ≤ 12 years, we demonstrated a sizeable circulation of different SARS-CoV-2 lineages over the four pandemic waves in paediatric population, sustained by local transmission chains. Age < 5 years, highest viral load, gamma and delta clades positively influence this local transmission. No correlations between COVID-19 manifestations and lineages or transmission chains are seen, except for a negative correlation between B.1.1.7 and hospitalization.
【초록키워드】 COVID-19, pandemic, Hospitalization, SARS-COV-2 infection, SARS-CoV-2 pandemic, children, severity, Local, Transmission, SARS-CoV-2 transmission, Viral load, B.1.1.7, Lineage, clade, clades, circulation, correlation, lineages, Frequency, manifestation, Virological, negative correlation, SARS-CoV-2 lineage, feature, defined, highest, demonstrated, sustained, SARS-CoV-2 positive patient, 【제목키워드】 COVID-19, children, SARS-CoV-2 variant, correlation,